Shinichi Sato, MD, PhD

Japan
Professor and Chairman, Department of Dermatology, the University of Tokyo, Japan
Education:
1989            M.D.  The University of Tokyo, Tokyo, JAPAN
1994            Ph.D. The University of Tokyo, Tokyo, JAPAN
University Appointments:
1989-1994 Assistant, Department of Dermatology, The University of Tokyo, Tokyo, JAPAN
1994-1997            Research Associate, Department of Immunology, Duke University Medical Center, Durham, NC, USA
1997-2002            Assistant Professor, Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, JAPAN
2002-2004            Associate Professor, Department of Dermatology, Kanazawa University, Graduate School of Medical Science, Kanazawa, JAPAN
2004-2009            Professor and Chairman, Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JAPAN
2009-                     Professor and Chairman, Department of Dermatology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
2015-2018            Vice President, The University of Tokyo Hospital
Awards:
2003            Japanese Society of Investigative Dermatology (JSID) Award
2005            Medical Award on Rheumatic Disease
2017                      Professor Lü Yau-Chin Memorial Lectureship (TDA)
Major Research Interests:
                                1. Scleroderma
                                2. B lymphocyte and Autoimmunity
                                3. Cell adhesion molecule and inflammation
Selected Publications (total 595 English publications):
  1. Sato S, Steeber DA, Tedder TF: The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc Natl Acad Sci USA 92:11558-62, 1995.
  2. Sato S, Miller AS, Inaoki M, Bock CB, Jansen PJ, Tang ML, Tedder TF: CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction. Immunity 5:551-62, 1996.
  3. Sato S, Jansen PJ, Tedder TF: CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc Natl Acad Sci USA 94:13158-62, 1997.
  4. Tedder TF, Inaoki M, Sato S: The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity 6:107-18, 1997.
  5. Sato S, Hasegawa M, Fujimoto M, Tedder TF, Takehara K: Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 165:6635-43, 2000.
  6. Saito E, Fujimoto M, Hasegawa M, Komura K, Hamaguchi Y, Kaburagi Y, Nagaoka T, Takehara K, Tedder TF, Sato S: CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. J Clin Invest 109:1453-62, 2002.
  7. Sato S, Fujimoto M, Hasegawa M, Takehara K: Altered blood B lymphocyte homeostasis in systemic sclerosis. Arthritis Rheum 50:1918-27, 2004.
  8. Noda S, Asano Y, Nishimura S, Taniguchi T, Fujiu K, Manabe I, Nakamura K,Yamashita T, Saigusa R, Akamata K, Takahashi T, Ichimura Y, Toyama T, Tsuruta D, Trojanowska M, Nagai R, Sato S: Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis. Nat Commun 5:5797, 2014.
  9. Shibata S