Shinichi Sato, MD, PhD

Japan
Professor and Chairman,<br> Department of Dermatology,<br> the University of Tokyo, Japan
Education:
1989            M.D.  The University of Tokyo, Tokyo, JAPAN
1994            Ph.D. The University of Tokyo, Tokyo, JAPAN
University Appointments:
1989-1994 Assistant, Department of Dermatology, The University of Tokyo, Tokyo
1994-1997            Research Associate, Department of Immunology, Duke University Medical Center, Durham, NC, USA
1997-2002            Assistant Professor, Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, JAPAN
2002-2004            Associate Professor, Department of Dermatology, Kanazawa University, Graduate School of Medical Science, Kanazawa, JAPAN
2004-2009            Professor and Chairman, Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, JAPAN
2009-                     Professor and Chairman, Department of Dermatology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, JAPAN
2015-                     Vice President, The University of Tokyo Hospital
Awards:
2003            Japanese Society of Investigative Dermatology (JSID) Award
2005            Abbott Japan-Medical Award on Rheumatic Disease
Major Research Interests:
                                1. Scleroderma
                                2. Autoimmunity and B lymphocyte
                                3. Cell adhesion molecule and inflammation

Selected Publications:
  1. Sato S, Steeber DA, Tedder TF: The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc Natl Acad Sci USA 92:11558-62, 1995.
  2. Sato S, Miller AS, Inaoki M, Bock CB, Jansen PJ, Tang ML, Tedder TF: CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction. Immunity 5:551-62, 1996.
  3. Sato S, Jansen PJ, Tedder TF: CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. Proc Natl Acad Sci USA 94:13158-62, 1997.
  4. Tedder TF, Inaoki M, Sato S: The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity. Immunity 6:107-18, 1997.
  5. Sato S, Hasegawa M, Fujimoto M, Tedder TF, Takehara K: Quantitative genetic variation in CD19 expression correlates with autoimmunity. J Immunol 165:6635-43, 2000.
  6. Nakatani T, Kaburagi Y, Shimada Y, Inaoki M, Takehara K, Mukaida N, Sato S: CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis. J Allergy Clin Immunol 107:353-8, 2001.
  7. Saito E, Fujimoto M, Hasegawa M, Komura K, Hamaguchi Y, Kaburagi Y, Nagaoka T, Takehara K, Tedder TF, Sato S: CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. J Clin Invest 109:1453-62, 2002.
  8. Sato S, Fujimoto M, Hasegawa M, Takehara K: Altered blood B lymphocyte homeostasis in systemic sclerosis. Arthritis Rheum 50:1918-27, 2004.
  9. Yoshizaki A, Iwata Y, Komura K, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Tedder TF, Sato S: CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scl